2qt0
From Proteopedia
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==Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue== | ==Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue== | ||
- | <StructureSection load='2qt0' size='340' side='right' caption='[[2qt0]], [[Resolution|resolution]] 1.92Å' scene=''> | + | <StructureSection load='2qt0' size='340' side='right'caption='[[2qt0]], [[Resolution|resolution]] 1.92Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2qt0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QT0 FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NNR:NICOTINAMIDE+RIBOSIDE'>NNR</scene></td></tr> |
- | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt0 OCA], [https://pdbe.org/2qt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qt0 RCSB], [https://www.ebi.ac.uk/pdbsum/2qt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qt0 ProSAT]</span></td></tr> |
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- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/NRK1_HUMAN NRK1_HUMAN] Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.<ref>PMID:15137942</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
- | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qt0_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qt0_consurf.spt"</scriptWhenChecked> |
- | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
- | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
- | [[Category: Bochkarev | + | [[Category: Arrowsmith CH]] |
- | [[Category: Brenner | + | [[Category: Bochkarev A]] |
- | [[Category: Edwards | + | [[Category: Brenner C]] |
- | [[Category: Landry | + | [[Category: Edwards AM]] |
- | [[Category: Nedyalkova | + | [[Category: Landry R]] |
- | [[Category: Park | + | [[Category: Nedyalkova L]] |
- | [[Category: Rabeh | + | [[Category: Park H]] |
- | + | [[Category: Rabeh WM]] | |
- | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
- | [[Category: Tempel | + | [[Category: Tempel W]] |
- | [[Category: Weigelt | + | [[Category: Weigelt J]] |
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Current revision
Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Brenner C | Edwards AM | Landry R | Nedyalkova L | Park H | Rabeh WM | Sundstrom M | Tempel W | Weigelt J