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2w20

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==STRUCTURE OF THE CATALYTIC DOMAIN OF THE NATIVE NANA SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE==
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<StructureSection load='2w20' size='340' side='right' caption='[[2w20]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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==Structure of the catalytic domain of the native NanA sialidase from Streptococcus pneumoniae==
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<StructureSection load='2w20' size='340' side='right'caption='[[2w20]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w20]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W20 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w20]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W20 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w20 OCA], [http://pdbe.org/2w20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w20 RCSB], [http://www.ebi.ac.uk/pdbsum/2w20 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w20 OCA], [https://pdbe.org/2w20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w20 RCSB], [https://www.ebi.ac.uk/pdbsum/2w20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w20 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NANA_STRR6 NANA_STRR6]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w20_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w20_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Neuraminidase|Neuraminidase]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Large Structures]]
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[[Category: Strr6]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Andrew, P W]]
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[[Category: Andrew PW]]
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[[Category: Taylor, G L]]
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[[Category: Taylor GL]]
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[[Category: Xu, G]]
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[[Category: Xu G]]
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[[Category: Cell wall]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Neuraminidase]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Secreted]]
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[[Category: Sialidase]]
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Current revision

Structure of the catalytic domain of the native NanA sialidase from Streptococcus pneumoniae

PDB ID 2w20

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