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3g2s

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==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==
==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==
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<StructureSection load='3g2s' size='340' side='right' caption='[[3g2s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3g2s' size='340' side='right'caption='[[3g2s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G2S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G2S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g2t|3g2t]], [[3g2u|3g2u]], [[3g2v|3g2v]], [[3g2w|3g2w]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://pdbe.org/3g2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [https://pdbe.org/3g2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [https://www.ebi.ac.uk/pdbsum/3g2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
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[https://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/3g2s_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/3g2s_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Behrens, M A]]
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[[Category: Large Structures]]
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[[Category: Cramer, J F]]
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[[Category: Behrens MA]]
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[[Category: Gustafsen, C]]
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[[Category: Cramer JF]]
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[[Category: Madsen, P]]
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[[Category: Gustafsen C]]
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[[Category: Oliveira, C L.P]]
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[[Category: Madsen P]]
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[[Category: Pedersen, J S]]
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[[Category: Oliveira CLP]]
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[[Category: Petersen, C M]]
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[[Category: Pedersen JS]]
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[[Category: Thirup, S S]]
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[[Category: Petersen CM]]
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[[Category: Acidic-cluster dileucine signal]]
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[[Category: Thirup SS]]
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[[Category: Adp-ribosylation factor binding protein gga1]]
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[[Category: Protein transport]]
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[[Category: Sorla]]
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[[Category: Vh]]
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Current revision

VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide

PDB ID 3g2s

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