This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3gqv
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP== | ==Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP== | ||
| - | <StructureSection load='3gqv' size='340' side='right' caption='[[3gqv]], [[Resolution|resolution]] 1.74Å' scene=''> | + | <StructureSection load='3gqv' size='340' side='right'caption='[[3gqv]], [[Resolution|resolution]] 1.74Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3gqv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3gqv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqv OCA], [https://pdbe.org/3gqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqv RCSB], [https://www.ebi.ac.uk/pdbsum/3gqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqv ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/LOVC_ASPTE LOVC_ASPTE] Catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the LovB-mediated biosynthesis of the lovastatin nonaketide chain.<ref>PMID:10334994</ref> <ref>PMID:19900898</ref> <ref>PMID:22733743</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 24: | Line 24: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Aspergillus terreus]] |
| - | [[Category: Ames | + | [[Category: Large Structures]] |
| - | [[Category: Kaake | + | [[Category: Ames BD]] |
| - | [[Category: Li | + | [[Category: Kaake R]] |
| - | [[Category: Ma | + | [[Category: Li JW]] |
| - | [[Category: Smith | + | [[Category: Ma SM]] |
| - | [[Category: Tang | + | [[Category: Smith PT]] |
| - | [[Category: Tsai | + | [[Category: Tang Y]] |
| - | [[Category: Vederas | + | [[Category: Tsai S-C]] |
| - | [[Category: Wong | + | [[Category: Vederas JC]] |
| - | [[Category: Wong | + | [[Category: Wong EW]] |
| - | [[Category: Xie | + | [[Category: Wong SK]] |
| - | + | [[Category: Xie X]] | |
| - | + | ||
| - | + | ||
Current revision
Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP
| |||||||||||
Categories: Aspergillus terreus | Large Structures | Ames BD | Kaake R | Li JW | Ma SM | Smith PT | Tang Y | Tsai S-C | Vederas JC | Wong EW | Wong SK | Xie X
