1g4d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:30, 22 May 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==NMR STRUCTURE OF THE MU BACTERIOPHAGE REPRESSOR DNA-BINDING DOMAIN/DNA COMPLEX==
==NMR STRUCTURE OF THE MU BACTERIOPHAGE REPRESSOR DNA-BINDING DOMAIN/DNA COMPLEX==
-
<StructureSection load='1g4d' size='340' side='right' caption='[[1g4d]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
+
<StructureSection load='1g4d' size='340' side='right'caption='[[1g4d]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1g4d]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpmu Bpmu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G4D FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1g4d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Mu Escherichia virus Mu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G4D FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qpm|1qpm]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MU C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10677 BPMU])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4d OCA], [https://pdbe.org/1g4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g4d RCSB], [https://www.ebi.ac.uk/pdbsum/1g4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g4d ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4d OCA], [http://pdbe.org/1g4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g4d RCSB], [http://www.ebi.ac.uk/pdbsum/1g4d PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/REPC_BPMU REPC_BPMU] Promotes latency by binding operators O1 and O2 in the enhancer/operator region, thereby repressing the transcription from the Pe (early) promoter and blocking the expression of the genes required for replication (lytic growth). Competes with DDE-recombinase A for binding to the internal activation sequence (IAS), which overlaps O1 and O2. The outcome of this competition determines if the virus enters latency or starts replication. Makes the cell immune to superinfection by repressing genes expression of any subsequent incoming viral genome.<ref>PMID:11517307</ref> <ref>PMID:12217693</ref> <ref>PMID:16154589</ref> <ref>PMID:18230617</ref> <ref>PMID:8626285</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g4d_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g4d_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 26: Line 28:
</div>
</div>
<div class="pdbe-citations 1g4d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1g4d" style="background-color:#fffaf0;"></div>
- 
-
==See Also==
 
-
*[[Bacteriophage repressor|Bacteriophage repressor]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bpmu]]
+
[[Category: Escherichia virus Mu]]
-
[[Category: Clubb, R T]]
+
[[Category: Large Structures]]
-
[[Category: Iwahara, J]]
+
[[Category: Clubb RT]]
-
[[Category: Wojciak, J M]]
+
[[Category: Iwahara J]]
-
[[Category: Bacteriophage mu]]
+
[[Category: Wojciak JM]]
-
[[Category: Helix-turn-helix]]
+
-
[[Category: Protein-dna complex]]
+
-
[[Category: Repressor]]
+
-
[[Category: Viral protein-dna complex]]
+
-
[[Category: Virus/viral protein]]
+
-
[[Category: Winged-helix]]
+

Current revision

NMR STRUCTURE OF THE MU BACTERIOPHAGE REPRESSOR DNA-BINDING DOMAIN/DNA COMPLEX

PDB ID 1g4d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g4d"
Personal tools