2vkv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:23, 13 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
==TETR (BD) VARIANT L17G WITH REVERSE PHENOTYPE==
+
 
-
<StructureSection load='2vkv' size='340' side='right' caption='[[2vkv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
+
==TetR (BD) variant L17G with reverse phenotype==
 +
<StructureSection load='2vkv' size='340' side='right'caption='[[2vkv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2vkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2vkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a6i|1a6i]], [[2vke|2vke]], [[1qpi|1qpi]], [[1bjz|1bjz]], [[1du7|1du7]], [[2trt|2trt]], [[1ork|1ork]], [[1bj0|1bj0]], [[2tct|2tct]], [[1bjy|1bjy]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkv OCA], [http://pdbe.org/2vkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vkv RCSB], [http://www.ebi.ac.uk/pdbsum/2vkv PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkv OCA], [https://pdbe.org/2vkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkv RCSB], [https://www.ebi.ac.uk/pdbsum/2vkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
+
[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkv_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkv_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 30: Line 31:
==See Also==
==See Also==
-
*[[Tetracycline repressor protein|Tetracycline repressor protein]]
+
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus coli migula 1895]]
+
[[Category: Escherichia coli]]
-
[[Category: Egerer-Sieber, C]]
+
[[Category: Large Structures]]
-
[[Category: Henssler, E M]]
+
[[Category: Egerer-Sieber C]]
-
[[Category: Hillen, W]]
+
[[Category: Henssler EM]]
-
[[Category: Muller, Y A]]
+
[[Category: Hillen W]]
-
[[Category: Resch, M]]
+
[[Category: Muller YA]]
-
[[Category: Schiltz, E]]
+
[[Category: Resch M]]
-
[[Category: Sevvana, M]]
+
[[Category: Schiltz E]]
-
[[Category: Striegl, H]]
+
[[Category: Sevvana M]]
-
[[Category: Anhydrotetracycline]]
+
[[Category: Striegl H]]
-
[[Category: Antibiotic resistance]]
+
-
[[Category: Bacterial repressor]]
+
-
[[Category: Disorder to order mechanism]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Helix-turn-helix motif]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Repressor]]
+
-
[[Category: Reverse phenotype]]
+
-
[[Category: Tetr]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+

Current revision

TetR (BD) variant L17G with reverse phenotype

PDB ID 2vkv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vkv"
Personal tools