We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
2o9k
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==WDR5 in Complex with Dimethylated H3K4 Peptide== | ==WDR5 in Complex with Dimethylated H3K4 Peptide== | ||
| - | <StructureSection load='2o9k' size='340' side='right' caption='[[2o9k]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='2o9k' size='340' side='right'caption='[[2o9k]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2o9k]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2o9k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2h9o 2h9o]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O9K FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o9k OCA], [https://pdbe.org/2o9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o9k RCSB], [https://www.ebi.ac.uk/pdbsum/2o9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o9k ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/2o9k_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/2o9k_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 30: | Line 31: | ||
==See Also== | ==See Also== | ||
| - | *[[WD-repeat protein | + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Allali-Hassani | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Allali-Hassani A]] |
| - | [[Category: Bochkarev | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Edwards | + | [[Category: Bochkarev A]] |
| - | [[Category: Loppnau | + | [[Category: Edwards AM]] |
| - | [[Category: Martin | + | [[Category: Loppnau P]] |
| - | [[Category: Min | + | [[Category: Martin F]] |
| - | [[Category: Plotnikov | + | [[Category: Min JR]] |
| - | + | [[Category: Plotnikov AN]] | |
| - | [[Category: Schuetz | + | [[Category: Schuetz A]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Vedadi | + | [[Category: Vedadi M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
WDR5 in Complex with Dimethylated H3K4 Peptide
| |||||||||||
Categories: Homo sapiens | Large Structures | Allali-Hassani A | Arrowsmith CH | Bochkarev A | Edwards AM | Loppnau P | Martin F | Min JR | Plotnikov AN | Schuetz A | Sundstrom M | Vedadi M | Weigelt J
