1u3i

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==Crystal structure of glutathione S-tranferase from Schistosoma mansoni==
==Crystal structure of glutathione S-tranferase from Schistosoma mansoni==
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<StructureSection load='1u3i' size='340' side='right' caption='[[1u3i]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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<StructureSection load='1u3i' size='340' side='right'caption='[[1u3i]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oe7|1oe7]], [[1oe8|1oe8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3i OCA], [https://pdbe.org/1u3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3i RCSB], [https://www.ebi.ac.uk/pdbsum/1u3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3i OCA], [http://pdbe.org/1u3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3i RCSB], [http://www.ebi.ac.uk/pdbsum/1u3i PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GST28_SCHMA GST28_SCHMA]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
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[https://www.uniprot.org/uniprot/GST28_SCHMA GST28_SCHMA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3i_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3i_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Glutathione S-transferase|Glutathione S-transferase]]
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Blood fluke]]
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[[Category: Large Structures]]
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[[Category: Glutathione transferase]]
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[[Category: Schistosoma mansoni]]
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[[Category: Capron, A]]
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[[Category: Capron A]]
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[[Category: Chomilier, J]]
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[[Category: Chomilier J]]
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[[Category: Labesse, G]]
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[[Category: Labesse G]]
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[[Category: Mormon, J P]]
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[[Category: Mormon J-P]]
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[[Category: Trottein, F]]
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[[Category: Trottein F]]
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[[Category: Vaney, M C]]
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[[Category: Vaney MC]]
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[[Category: Gst fold]]
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[[Category: Transferase]]
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Current revision

Crystal structure of glutathione S-tranferase from Schistosoma mansoni

PDB ID 1u3i

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