1jac

<StructureSection load='1jac' size='340' side='right' caption='[[1jac]], [[Resolution|resolution]] 2.43&Aring;' scene=''>

<table><tr><td colspan='2'>[[1jac]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Artocarpus_heterophyllus Artocarpus heterophyllus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JAC FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMG:ALPHA-METHYL-D-GALACTOSIDE'>AMG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jac OCA], [http://pdbe.org/1jac PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jac RCSB], [http://www.ebi.ac.uk/pdbsum/1jac PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum. [[http://www.uniprot.org/uniprot/LECB1_ARTIN LECB1_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/1jac_consurf.spt"</scriptWhenChecked>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Jacalin, a tetrameric two-chain lectin (66,000 Mr) from jackfruit seeds, is highly specific for the tumour associated T-antigenic disaccharide. The crystal structure of jacalin with methyl-alpha-D-galactose reveals that each subunit has a three-fold symmetric beta-prism fold made up of three four-stranded beta-sheets. The lectin exhibits a novel carbohydrate-binding site involving the N terminus of the alpha-chain which is generated through a post-translational modification involving proteolysis, the first known instance where such a modification has been used to confer carbohydrate specificity. This new lectin fold may be characteristic of the Moraceae plant family. The structure provides an explanation for the relative affinities of the lectin for galactose derivatives and provides insights into the structural basis of its T-antigen specificity.

A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a beta-prism fold.,Sankaranarayanan R, Sekar K, Banerjee R, Sharma V, Surolia A, Vijayan M Nat Struct Biol. 1996 Jul;3(7):596-603. PMID:8673603<ref>PMID:8673603</ref>

== References ==

[[Category: Banerjee, R]]

[[Category: Sankaranarayanan, R]]

[[Category: Sekar, K]]

[[Category: Sharma, V]]

[[Category: Surolia, A]]

[[Category: Vijayan, M]]

[[Category: Non-legume]]