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| - | [[Image:1d96.gif|left|200px]] | |
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| - | {{Structure
| + | ==MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA== |
| - | |PDB= 1d96 |SIZE=350|CAPTION= <scene name='initialview01'>1d96</scene>, resolution 2.000Å
| + | <StructureSection load='1d96' size='340' side='right'caption='[[1d96]], [[Resolution|resolution]] 2.00Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>
| + | <table><tr><td colspan='2'>[[1d96]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D96 FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d96 OCA], [https://pdbe.org/1d96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d96 RCSB], [https://www.ebi.ac.uk/pdbsum/1d96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d96 ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d96 OCA], [http://www.ebi.ac.uk/pdbsum/1d96 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d96 RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Fujii S]] |
| - | '''MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA'''
| + | [[Category: Rich A]] |
| - | | + | [[Category: Van Boeckel SAA]] |
| - | | + | [[Category: Van Boom JH]] |
| - | ==Overview==
| + | [[Category: Van Der Marel GA]] |
| - | The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.
| + | [[Category: Wang AH-J]] |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1D96 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D96 OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA., Wang AH, Fujii S, van Boom JH, van der Marel GA, van Boeckel SA, Rich A, Nature. 1982 Oct 14;299(5884):601-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6181416 6181416]
| + | |
| - | [[Category: Protein complex]]
| + | |
| - | [[Category: Boeckel, S A.A Van.]]
| + | |
| - | [[Category: Boom, J H.Van.]] | + | |
| - | [[Category: Fujii, S.]] | + | |
| - | [[Category: Marel, G A.Van Der.]] | + | |
| - | [[Category: Rich, A.]] | + | |
| - | [[Category: Wang, A H.J.]] | + | |
| - | [[Category: a-dna/rna]] | + | |
| - | [[Category: double helix]] | + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:37:01 2008''
| + | |
