1btv

From Proteopedia

(Difference between revisions)

Current revision

STRUCTURE OF BET V 1, NMR, 20 STRUCTURES

Structural highlights

1btv is a 1 chain structure with sequence from Betula pendula. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BEV1A_BETPN May be a general steroid carrier protein (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.

X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.,Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1btv"

@@ Line 1: / Line 1: @@
 ==STRUCTURE OF BET V 1, NMR, 20 STRUCTURES==
-<StructureSection load='1btv' size='340' side='right' caption='[[1btv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1btv' size='340' side='right'caption='[[1btv]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1btv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betpn Betpn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BTV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1btv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BTV FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btv OCA], [http://pdbe.org/1btv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1btv RCSB], [http://www.ebi.ac.uk/pdbsum/1btv PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btv OCA], [https://pdbe.org/1btv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1btv RCSB], [https://www.ebi.ac.uk/pdbsum/1btv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1btv ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).
+[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN] May be a general steroid carrier protein (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/1btv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/1btv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 30: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Betpn]]
+[[Category: Betula pendula]]
-[[Category: Gajhede, M]]
+[[Category: Large Structures]]
-[[Category: Larsen, J N]]
+[[Category: Gajhede M]]
-[[Category: Osmark, P]]
+[[Category: Larsen JN]]
-[[Category: Poulsen, F M]]
+[[Category: Osmark P]]
-[[Category: Spangfort, M D]]
+[[Category: Poulsen FM]]
-[[Category: Ige-allergy]]
+[[Category: Spangfort MD]]
-[[Category: Major birch pollen allergen]]
-[[Category: Pr-10 protein]]

1btv

From Proteopedia

Current revision

STRUCTURE OF BET V 1, NMR, 20 STRUCTURES

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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