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| - | [[Image:1dc0.gif|left|200px]] | |
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| - | {{Structure
| + | ==CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG== |
| - | |PDB= 1dc0 |SIZE=350|CAPTION= <scene name='initialview01'>1dc0</scene>, resolution 1.3Å
| + | <StructureSection load='1dc0' size='340' side='right'caption='[[1dc0]], [[Resolution|resolution]] 1.30Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>
| + | <table><tr><td colspan='2'>[[1dc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DC0 FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc0 OCA], [https://pdbe.org/1dc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dc0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc0 ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc0 OCA], [http://www.ebi.ac.uk/pdbsum/1dc0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dc0 RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Dickerson RE]] |
| - | '''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG'''
| + | [[Category: Kopka ML]] |
| - | | + | [[Category: Ng HL]] |
| - | | + | |
| - | ==Overview==
| + | |
| - | The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1DC0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10688897 10688897]
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| - | [[Category: Protein complex]] | + | |
| - | [[Category: Dickerson, R E.]] | + | |
| - | [[Category: Kopka, M L.]] | + | |
| - | [[Category: Ng, H. L.]] | + | |
| - | [[Category: a-dna]]
| + | |
| - | [[Category: b-dna]]
| + | |
| - | [[Category: intermediate]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:38:35 2008''
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