1lsl

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==Crystal Structure of the Thrombospondin-1 Type 1 Repeats==
==Crystal Structure of the Thrombospondin-1 Type 1 Repeats==
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<StructureSection load='1lsl' size='340' side='right' caption='[[1lsl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1lsl' size='340' side='right'caption='[[1lsl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1lsl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LSL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1lsl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LSL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THBS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lsl OCA], [http://pdbe.org/1lsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lsl RCSB], [http://www.ebi.ac.uk/pdbsum/1lsl PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lsl OCA], [https://pdbe.org/1lsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lsl RCSB], [https://www.ebi.ac.uk/pdbsum/1lsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lsl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TSP1_HUMAN TSP1_HUMAN]] Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties.<ref>PMID:11134179</ref> <ref>PMID:15014436</ref>
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[https://www.uniprot.org/uniprot/TSP1_HUMAN TSP1_HUMAN] Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties.<ref>PMID:11134179</ref> <ref>PMID:15014436</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1lsl_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1lsl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1lsl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1lsl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thrombospondin|Thrombospondin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dong, Y]]
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[[Category: Large Structures]]
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[[Category: Duquette, M]]
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[[Category: Dong Y]]
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[[Category: Joachimiak, A]]
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[[Category: Duquette M]]
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[[Category: Lawler, J]]
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[[Category: Joachimiak A]]
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[[Category: Liu, J]]
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[[Category: Lawler J]]
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[[Category: Tan, K]]
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[[Category: Liu J]]
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[[Category: Wang, J H]]
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[[Category: Tan K]]
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[[Category: Zhang, R]]
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[[Category: Wang J-H]]
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[[Category: Cell adhesion]]
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[[Category: Zhang R]]
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[[Category: Tsp-1]]
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[[Category: Tsr]]
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Current revision

Crystal Structure of the Thrombospondin-1 Type 1 Repeats

PDB ID 1lsl

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