1dde

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[[Image:1dde.gif|left|200px]]
 
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{{Structure
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==STRUCTURE OF THE DNAG CATALYTIC CORE==
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|PDB= 1dde |SIZE=350|CAPTION= <scene name='initialview01'>1dde</scene>, resolution 1.7&Aring;
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<StructureSection load='1dde' size='340' side='right'caption='[[1dde]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=Y1:YTTRIUM+ION'>Y1</scene>
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<table><tr><td colspan='2'>[[1dde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DDE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y1:YTTRIUM+ION'>Y1</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dde OCA], [https://pdbe.org/1dde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dde RCSB], [https://www.ebi.ac.uk/pdbsum/1dde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dde ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1dd9|1DD9]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dde OCA], [http://www.ebi.ac.uk/pdbsum/1dde PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dde RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DNAG_ECOLI DNAG_ECOLI] RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.[HAMAP-Rule:MF_00974]<ref>PMID:1511009</ref> <ref>PMID:340457</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1dde_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dde ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF THE DNAG CATALYTIC CORE'''
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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==Overview==
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<references/>
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All cellular organisms use specialized RNA polymerases called "primases" to synthesize RNA primers for the initiation of DNA replication. The high-resolution crystal structure of a primase, comprising the catalytic core of the Escherichia coli DnaG protein, was determined. The core structure contains an active-site architecture that is unrelated to other DNA or RNA polymerase palm folds, but is instead related to the "toprim" fold. On the basis of the structure, it is likely that DnaG binds nucleic acid in a groove clustered with invariant residues and that DnaG is positioned within the replisome to accept single-stranded DNA directly from the replicative helicase.
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__TOC__
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</StructureSection>
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==About this Structure==
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1DDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDE OCA].
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==Reference==
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Structure of the RNA polymerase domain of E. coli primase., Keck JL, Roche DD, Lynch AS, Berger JM, Science. 2000 Mar 31;287(5462):2482-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10741967 10741967]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Berger, J M.]]
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[[Category: Berger JM]]
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[[Category: Keck, J L.]]
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[[Category: Keck JL]]
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[[Category: Lynch, A S.]]
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[[Category: Lynch AS]]
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[[Category: Roche, D D.]]
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[[Category: Roche DD]]
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[[Category: 3-helix bundle]]
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[[Category: dna-binding protein]]
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[[Category: primase]]
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[[Category: replication protein]]
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[[Category: rna polymerase]]
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[[Category: toprim]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:39:25 2008''
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Current revision

STRUCTURE OF THE DNAG CATALYTIC CORE

PDB ID 1dde

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