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2han

From Proteopedia

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==Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter==
==Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter==
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<StructureSection load='2han' size='340' side='right' caption='[[2han]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='2han' size='340' side='right'caption='[[2han]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2han]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2han]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">usp, Cf1, NR2B4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), EcR, NR1H1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2han FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2han OCA], [http://pdbe.org/2han PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2han RCSB], [http://www.ebi.ac.uk/pdbsum/2han PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2han FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2han OCA], [https://pdbe.org/2han PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2han RCSB], [https://www.ebi.ac.uk/pdbsum/2han PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2han ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ECR_DROME ECR_DROME]] Receptor for ecdysone. Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes.<ref>PMID:1913820</ref> [[http://www.uniprot.org/uniprot/USP_DROME USP_DROME]] Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
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[https://www.uniprot.org/uniprot/USP_DROME USP_DROME] Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2han_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2han_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Dutko-Gwozdz, J]]
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[[Category: Large Structures]]
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[[Category: Gwozdz, T]]
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[[Category: Dutko-Gwozdz J]]
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[[Category: Jakob, M]]
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[[Category: Gwozdz T]]
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[[Category: Jaskolski, M]]
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[[Category: Jakob M]]
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[[Category: Kochman, M]]
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[[Category: Jaskolski M]]
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[[Category: Kolodziejczyk, R]]
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[[Category: Kochman M]]
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[[Category: Kowalska, A]]
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[[Category: Kolodziejczyk R]]
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[[Category: Krzywda, S]]
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[[Category: Kowalska A]]
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[[Category: Orlowski, M]]
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[[Category: Krzywda S]]
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[[Category: Ozyhar, A]]
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[[Category: Orlowski M]]
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[[Category: Dna-binding]]
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[[Category: Ozyhar A]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription factor]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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[[Category: Zinc finger]]
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Current revision

Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter

PDB ID 2han

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