1d4b

From Proteopedia

(Difference between revisions)

Current revision

CIDE-N DOMAIN OF HUMAN CIDE-B

Structural highlights

1d4b is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CIDEB_HUMAN Activates apoptosis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Apoptotic DNA fragmentation and chromatin condensation are mediated by the caspase-activated DFF40/ CAD nuclease, which is chaperoned and inhibited by DFF45/ICAD. CIDE proteins share a homologous regulatory CIDE-N domain with DFF40/CAD and DFF45/ ICAD. Here we report the solution structure of CIDE-N of human CIDE-B. We show that the CIDE-N of CIDE-B interacts with CIDE-N domains of both DFF40 and DFF45. The binding epitopes are similar and map to a highly charged bipolar surface region of CIDE-B. Furthermore, we demonstrate that the CIDE-N of CIDE-B regulates enzymatic activity of the DFF40/ DFF45 complex in vitro. Based on these results and mutagenesis data, we propose a model for the CIDE-N/ CIDE-N complex and discuss the role of this novel bipolar interaction in mediating downstream events of apoptosis.

Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.,Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G Cell. 1999 Dec 23;99(7):747-55. PMID:10619428^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell. 1999 Dec 23;99(7):747-55. PMID:10619428

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1d4b"

@@ Line 1: / Line 1: @@
 ==CIDE-N DOMAIN OF HUMAN CIDE-B==
-<StructureSection load='1d4b' size='340' side='right' caption='[[1d4b]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+<StructureSection load='1d4b' size='340' side='right'caption='[[1d4b]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1d4b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D4B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1d4b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D4B FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d4b OCA], [http://pdbe.org/1d4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d4b RCSB], [http://www.ebi.ac.uk/pdbsum/1d4b PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d4b OCA], [https://pdbe.org/1d4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d4b RCSB], [https://www.ebi.ac.uk/pdbsum/1d4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d4b ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CIDEB_HUMAN CIDEB_HUMAN]] Activates apoptosis.
+[https://www.uniprot.org/uniprot/CIDEB_HUMAN CIDEB_HUMAN] Activates apoptosis.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/1d4b_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/1d4b_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 30: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Chou, J]]
+[[Category: Large Structures]]
-[[Category: Li, P]]
+[[Category: Chou J]]
-[[Category: Lugovskoy, A]]
+[[Category: Li P]]
-[[Category: McCarty, J]]
+[[Category: Lugovskoy A]]
-[[Category: Wagner, G]]
+[[Category: McCarty J]]
-[[Category: Zhou, P]]
+[[Category: Wagner G]]
-[[Category: Alpha/beta roll]]
+[[Category: Zhou P]]
-[[Category: Apoptosis]]

1d4b

From Proteopedia

Current revision

CIDE-N DOMAIN OF HUMAN CIDE-B

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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