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3a2b

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==Crystal Structure of Serine Palmitoyltransferase from Sphingobacterium multivorum with substrate L-serine==
==Crystal Structure of Serine Palmitoyltransferase from Sphingobacterium multivorum with substrate L-serine==
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<StructureSection load='3a2b' size='340' side='right' caption='[[3a2b]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3a2b' size='340' side='right'caption='[[3a2b]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a2b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"cytophaga_keratolytica"_(kitamikado_and_ito_1979)_imai_1985 "cytophaga keratolytica" (kitamikado and ito 1979) imai 1985]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A2B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobacterium_multivorum Sphingobacterium multivorum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A2B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28454 "Cytophaga keratolytica" (Kitamikado and Ito 1979) Imai 1985])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_C-palmitoyltransferase Serine C-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.50 2.3.1.50] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a2b OCA], [https://pdbe.org/3a2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a2b RCSB], [https://www.ebi.ac.uk/pdbsum/3a2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a2b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a2b OCA], [http://pdbe.org/3a2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a2b RCSB], [http://www.ebi.ac.uk/pdbsum/3a2b PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPT_SPHMU SPT_SPHMU] Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:17557831). Exhibits a broad substrate specificity concerning the chain length and the degree of unsaturation of acyl-CoA (PubMed:17557831).<ref>PMID:17557831</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/3a2b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/3a2b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Serine palmitoyltransferase|Serine palmitoyltransferase]]
*[[Serine palmitoyltransferase|Serine palmitoyltransferase]]
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*[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Serine C-palmitoyltransferase]]
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[[Category: Large Structures]]
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[[Category: Hoseki, J]]
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[[Category: Sphingobacterium multivorum]]
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[[Category: Okamoto, A]]
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[[Category: Hoseki J]]
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[[Category: Acyltransferase]]
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[[Category: Okamoto A]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Transferase]]
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[[Category: Vitamin b6-dependent enzyme fold type i]]
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Current revision

Crystal Structure of Serine Palmitoyltransferase from Sphingobacterium multivorum with substrate L-serine

PDB ID 3a2b

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