1dlc

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[[Image:1dlc.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN FROM BACILLUS THURINGIENSIS AT 2.5 ANGSTROMS RESOLUTION==
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|PDB= 1dlc |SIZE=350|CAPTION= <scene name='initialview01'>1dlc</scene>, resolution 2.5&Aring;
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<StructureSection load='1dlc' size='340' side='right'caption='[[1dlc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1dlc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLC FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlc OCA], [https://pdbe.org/1dlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlc RCSB], [https://www.ebi.ac.uk/pdbsum/1dlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlc ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlc OCA], [http://www.ebi.ac.uk/pdbsum/1dlc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dlc RCSB]</span>
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[https://www.uniprot.org/uniprot/CR3AA_BACTT CR3AA_BACTT] Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlc ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN FROM BACILLUS THURINGIENSIS AT 2.5 ANGSTROMS RESOLUTION'''
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==See Also==
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*[[Delta-endotoxin|Delta-endotoxin]]
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__TOC__
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==Overview==
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</StructureSection>
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The structure of the delta-endotoxin from Bacillus thuringiensis subsp. tenebrionis that is specifically toxic to Coleoptera insects (beetle toxin) has been determined at 2.5 A resolution. It comprises three domains which are, from the N- to C-termini, a seven-helix bundle, a three-sheet domain, and a beta sandwich. The core of the molecule encompassing all the domain interfaces is built from conserved sequence segments of the active delta-endotoxins. Therefore the structure represents the general fold of this family of insecticidal proteins. The bundle of long, hydrophobic and amphipathic helices is equipped for pore formation in the insect membrane, and regions of the three-sheet domain are probably responsible for receptor binding.
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==About this Structure==
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1DLC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLC OCA].
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==Reference==
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Crystal structure of insecticidal delta-endotoxin from Bacillus thuringiensis at 2.5 A resolution., Li JD, Carroll J, Ellar DJ, Nature. 1991 Oct 31;353(6347):815-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1658659 1658659]
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[[Category: Bacillus thuringiensis]]
[[Category: Bacillus thuringiensis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:43:46 2008''
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Current revision

CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN FROM BACILLUS THURINGIENSIS AT 2.5 ANGSTROMS RESOLUTION

PDB ID 1dlc

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