3eoa

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==Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I==
==Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I==
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<StructureSection load='3eoa' size='340' side='right' caption='[[3eoa]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3eoa' size='340' side='right'caption='[[3eoa]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3eoa]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3eoa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EOA FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eo9|3eo9]], [[3eob|3eob]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGAL, CD11A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoa OCA], [https://pdbe.org/3eoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eoa RCSB], [https://www.ebi.ac.uk/pdbsum/3eoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eoa ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoa OCA], [http://pdbe.org/3eoa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eoa RCSB], [http://www.ebi.ac.uk/pdbsum/3eoa PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
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[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoa_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Integrin|Integrin]]
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*[[Integrin 3D structures|Integrin 3D structures]]
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ding, J]]
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[[Category: Large Structures]]
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[[Category: Li, S]]
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[[Category: Ding J]]
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[[Category: Antibody]]
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[[Category: Li S]]
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[[Category: Cd11a]]
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[[Category: Efalizumab]]
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[[Category: Fab]]
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[[Category: Glycoprotein]]
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[[Category: I domain]]
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[[Category: Immune system-cell adhesion complex]]
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[[Category: Integrin]]
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[[Category: Lfa-1]]
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[[Category: Magnesium]]
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[[Category: Membrane]]
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[[Category: Receptor]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I

PDB ID 3eoa

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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