1dm8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:56, 7 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dm8.gif|left|200px]]
 
-
{{Structure
+
==BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)==
-
|PDB= 1dm8 |SIZE=350|CAPTION= <scene name='initialview01'>1dm8</scene>, resolution 2.25&Aring;
+
<StructureSection load='1dm8' size='340' side='right'caption='[[1dm8]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TZC:1,2,4-TRIAZOLE-CARBOXAMIDINE'>TZC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[1dm8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DM8 FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TZC:1,2,4-TRIAZOLE-CARBOXAMIDINE'>TZC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dm8 OCA], [https://pdbe.org/1dm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dm8 RCSB], [https://www.ebi.ac.uk/pdbsum/1dm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dm8 ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[4nse|4NSE]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dm8 OCA], [http://www.ebi.ac.uk/pdbsum/1dm8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dm8 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/1dm8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dm8 ConSurf].
 +
<div style="clear:both"></div>
-
'''BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)'''
+
==See Also==
-
 
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1DM8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DM8 OCA].
+
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Nitric-oxide synthase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Li H]]
-
[[Category: Li, H.]]
+
[[Category: Martasek P]]
-
[[Category: Martasek, P.]]
+
[[Category: Masters BSS]]
-
[[Category: Masters, B S.S.]]
+
[[Category: Poulos TL]]
-
[[Category: Poulos, T L.]]
+
[[Category: Raman CS]]
-
[[Category: Raman, C S.]]
+
[[Category: Southan GJ]]
-
[[Category: Southan, G J.]]
+
-
[[Category: alpha-beta fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:44:23 2008''
+

Current revision

BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)

PDB ID 1dm8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dm8"
Personal tools