2g76

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Current revision

Crystal structure of human 3-phosphoglycerate dehydrogenase

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 ==Crystal structure of human 3-phosphoglycerate dehydrogenase==
-<StructureSection load='2g76' size='340' side='right' caption='[[2g76]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+<StructureSection load='2g76' size='340' side='right'caption='[[2g76]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2g76]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G76 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2g76]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G76 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHGDH, PGDH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [https://pdbe.org/2g76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB], [https://www.ebi.ac.uk/pdbsum/2g76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g76 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [http://pdbe.org/2g76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB], [http://www.ebi.ac.uk/pdbsum/2g76 PDBsum]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
+[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
+== Function ==
+[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g76_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g76_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 25: / Line 27: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Phosphoglycerate dehydrogenase]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C]]
+[[Category: Arrowsmith C]]
-[[Category: Delft, F von]]
+[[Category: Edwards A]]
-[[Category: Edwards, A]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O]]
+[[Category: Oppermann U]]
-[[Category: Oppermann, U]]
+[[Category: Salah E]]
-[[Category: Structural genomic]]
+[[Category: Savitsky P]]
-[[Category: Salah, E]]
+[[Category: Sundstrom M]]
-[[Category: Savitsky, P]]
+[[Category: Turnbull AP]]
-[[Category: Sundstrom, M]]
+[[Category: Weigelt J]]
-[[Category: Turnbull, A P]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J]]
-[[Category: 2-hydroxyacid dehydrogenase]]
-[[Category: Oxidoreductase]]
-[[Category: Phosphoglycerate dehydrogenase deficiency]]
-[[Category: Serine metabolism]]
-[[Category: Sgc]]

2g76

From Proteopedia

Current revision

Crystal structure of human 3-phosphoglycerate dehydrogenase

Structural highlights

Disease

Function

Evolutionary Conservation

See Also

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