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2aff

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==The solution structure of the Ki67FHA/hNIFK(226-269)3P complex==
==The solution structure of the Ki67FHA/hNIFK(226-269)3P complex==
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<StructureSection load='2aff' size='340' side='right' caption='[[2aff]], [[NMR_Ensembles_of_Models | 100 NMR models]]' scene=''>
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<StructureSection load='2aff' size='340' side='right'caption='[[2aff]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2aff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AFF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2aff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AFF FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 100 models</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r21|1r21]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MKI67 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MKI67IP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aff OCA], [https://pdbe.org/2aff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aff RCSB], [https://www.ebi.ac.uk/pdbsum/2aff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aff ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aff OCA], [http://pdbe.org/2aff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aff RCSB], [http://www.ebi.ac.uk/pdbsum/2aff PDBsum]</span></td></tr>
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</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KI67_HUMAN KI67_HUMAN]] Thought to be required for maintaining cell proliferation.
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[https://www.uniprot.org/uniprot/KI67_HUMAN KI67_HUMAN] Thought to be required for maintaining cell proliferation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2aff_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2aff_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Byeon, I J.L]]
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[[Category: Large Structures]]
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[[Category: Gronenborn, A M]]
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[[Category: Byeon I-JL]]
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[[Category: Li, H]]
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[[Category: Gronenborn AM]]
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[[Category: Song, H]]
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[[Category: Li H]]
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[[Category: Tsai, M D]]
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[[Category: Song H]]
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[[Category: Cell cycle]]
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[[Category: Tsai MD]]
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[[Category: Fha]]
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[[Category: Ki67]]
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[[Category: Nifk]]
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[[Category: Nmr]]
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[[Category: Phosphoprotein]]
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Current revision

The solution structure of the Ki67FHA/hNIFK(226-269)3P complex

PDB ID 2aff

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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