1dsm

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[[Image:1dsm.gif|left|200px]]
 
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{{Structure
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==(-)-duocarmycin SA covalently linked to duplex DNA==
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|PDB= 1dsm |SIZE=350|CAPTION= <scene name='initialview01'>1dsm</scene>
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<StructureSection load='1dsm' size='340' side='right'caption='[[1dsm]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DSA:4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC+ACID+METHYL+ESTER'>DSA</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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<table><tr><td colspan='2'>[[1dsm]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DSM FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSA:4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC+ACID+METHYL+ESTER'>DSA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dsm OCA], [https://pdbe.org/1dsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dsm RCSB], [https://www.ebi.ac.uk/pdbsum/1dsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dsm ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dsm OCA], [http://www.ebi.ac.uk/pdbsum/1dsm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dsm RCSB]</span>
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<div style="background-color:#fffaf0;">
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}}
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== Publication Abstract from PubMed ==
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'''(-)-duocarmycin SA covalently linked to duplex DNA'''
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==Overview==
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Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.
Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.
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==About this Structure==
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The structural basis for in situ activation of DNA alkylation by duocarmycin SA.,Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:10903864<ref>PMID:10903864</ref>
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1DSM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
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==Reference==
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The structural basis for in situ activation of DNA alkylation by duocarmycin SA., Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ, J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10903864 10903864]
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[[Category: Protein complex]]
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[[Category: Case, D A.]]
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[[Category: Chazin, W J.]]
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[[Category: Smith, J A.]]
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[[Category: antitumor agent]]
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[[Category: dna]]
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[[Category: drug-dna complex]]
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[[Category: duocarmycin]]
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[[Category: minor groove binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:47:56 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1dsm" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Case DA]]
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[[Category: Chazin WJ]]
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[[Category: Smith JA]]

Current revision

(-)-duocarmycin SA covalently linked to duplex DNA

PDB ID 1dsm

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