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2vp7

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==DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT SIGNALING COMPLEX==
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<StructureSection load='2vp7' size='340' side='right' caption='[[2vp7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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==Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex==
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<StructureSection load='2vp7' size='340' side='right'caption='[[2vp7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VP7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vp7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VP7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vpg|2vpg]], [[2vpe|2vpe]], [[2vpb|2vpb]], [[2vpd|2vpd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp7 OCA], [http://pdbe.org/2vp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vp7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vp7 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp7 OCA], [https://pdbe.org/2vp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vp7 RCSB], [https://www.ebi.ac.uk/pdbsum/2vp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vp7 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).<ref>PMID:11955446</ref>
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[https://www.uniprot.org/uniprot/PYGO1_HUMAN PYGO1_HUMAN] Involved in signal transduction through the Wnt pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vp7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bienz, M]]
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[[Category: Large Structures]]
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[[Category: Evans, P]]
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[[Category: Bienz M]]
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[[Category: Fiedler, M]]
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[[Category: Evans P]]
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[[Category: Mieszczanek, J]]
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[[Category: Fiedler M]]
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[[Category: Muller, J]]
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[[Category: Mieszczanek J]]
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[[Category: Nekrasov, M]]
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[[Category: Muller J]]
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[[Category: Rybin, V]]
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[[Category: Nekrasov M]]
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[[Category: Sanchez-Barrena, M J]]
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[[Category: Rybin V]]
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[[Category: Bcl9 hd1 domain]]
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[[Category: Sanchez-Barrena MJ]]
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[[Category: Gene regulation]]
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[[Category: Histone h3k4me2 tail]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Pygo phd domain]]
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[[Category: Signaling protein]]
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[[Category: Wnt signaling complex]]
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[[Category: Wnt signaling pathway]]
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[[Category: Zinc-finger]]
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Current revision

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

PDB ID 2vp7

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