Ecotin
From Proteopedia
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| - | <StructureSection load='1id5' size='400' side='right' scene='46/465444/Cv/ | + | <StructureSection load='1id5' size='400' side='right' scene='46/465444/Cv/2' caption='The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) [[1id5]]'> |
'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of ''E. coli''. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.<ref>PMID:14705961</ref> | '''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of ''E. coli''. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.<ref>PMID:14705961</ref> | ||
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| + | <scene name='46/465444/Cv/7'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/8'>thrombin heavy and light chains</scene>. | ||
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| + | <scene name='46/465444/Cv/9'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Ecotin == | == 3D Structures of Ecotin == | ||
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**[[1fi8]] - ECO (mutant) + granzyme B<br /> | **[[1fi8]] - ECO (mutant) + granzyme B<br /> | ||
**[[4iw4]] – ECO + mannan-binding lectin serine protease<br /> | **[[4iw4]] – ECO + mannan-binding lectin serine protease<br /> | ||
| + | **[[7cbk]] – ECO + elastase<br /> | ||
| + | **[[7pqo]] – ECO (mutant) + MASP-1<br /> | ||
| + | **[[7pqn]] – ECO + MASP-2<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Ecotin
Updated on 08-February-2023
References
- ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:http://dx.doi.org/10.1042/BJ20031790
- ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582
