1dxg

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[[Image:1dxg.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF DESULFOREDOXIN FROM DESULFOVIBRIO GIGAS AT 1.8 A RESOLUTION==
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|PDB= 1dxg |SIZE=350|CAPTION= <scene name='initialview01'>1dxg</scene>, resolution 1.8&Aring;
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<StructureSection load='1dxg' size='340' side='right'caption='[[1dxg]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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<table><tr><td colspan='2'>[[1dxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Megalodesulfovibrio_gigas Megalodesulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXG FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxg OCA], [https://pdbe.org/1dxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxg RCSB], [https://www.ebi.ac.uk/pdbsum/1dxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxg ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxg OCA], [http://www.ebi.ac.uk/pdbsum/1dxg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dxg RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DESR_MEGGA DESR_MEGGA] Nonheme iron protein possibly involved in electron transport.
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== Evolutionary Conservation ==
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'''CRYSTAL STRUCTURE OF DESULFOREDOXIN FROM DESULFOVIBRIO GIGAS AT 1.8 A RESOLUTION'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxg_consurf.spt"</scriptWhenChecked>
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The crystal structure of desulforedoxin from Desulfovibrio gigas, a new homo-dimeric (2 x 36 amino acids) non-heme iron protein, has been solved by the SIRAS method using the indium-substituted protein as the single derivative. The structure was refined to a crystallographic R-factor of 16.9% at 1.8 A resolution. Native desulforedoxin crystals were grown from either PEG 4K or lithium sulfate, with cell constants a = b = 42.18 A, c = 72.22 A (for crystals grown from PEG 4K), and they belong to space group P3(2)21. The indium-substituted protein crystallized isomorphously under the same conditions. The 2-fold symmetric dimer is firmly hydrogen bonded and folds as an incomplete beta-barrel with the two iron centers placed on opposite poles of the molecule. Each iron atom is coordinated to four cysteinyl residues in a distorted tetrahedral arrangement. Both iron atoms are 16 A apart but connected across the 2-fold axis by 14 covalent bonds along the polypeptide chain plus two hydrogen bonds. Desulforedoxin and rubredoxin share some structural features but show significant differences in terms of metal environment and water structure, which account for the known spectroscopic differences between rubredoxin and desulforedoxin.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1DXG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXG OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dxg ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of desulforedoxin from Desulfovibrio gigas determined at 1.8 A resolution: a novel non-heme iron protein structure., Archer M, Huber R, Tavares P, Moura I, Moura JJ, Carrondo MA, Sieker LC, LeGall J, Romao MJ, J Mol Biol. 1995 Sep 1;251(5):690-702. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7666420 7666420]
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</StructureSection>
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[[Category: Desulfovibrio gigas]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Megalodesulfovibrio gigas]]
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[[Category: Archer, M.]]
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[[Category: Archer M]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Romao, M J.]]
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[[Category: Romao MJ]]
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[[Category: electron transport]]
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[[Category: non-heme iron protein]]
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[[Category: rubredoxin type metal center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:50:41 2008''
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Current revision

CRYSTAL STRUCTURE OF DESULFOREDOXIN FROM DESULFOVIBRIO GIGAS AT 1.8 A RESOLUTION

PDB ID 1dxg

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