1dxh

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[[Image:1dxh.gif|left|200px]]
 
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{{Structure
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==Catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa==
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|PDB= 1dxh |SIZE=350|CAPTION= <scene name='initialview01'>1dxh</scene>, resolution 2.50&Aring;
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<StructureSection load='1dxh' size='340' side='right'caption='[[1dxh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1dxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXH FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_carbamoyltransferase Ornithine carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.3 2.1.3.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxh OCA], [https://pdbe.org/1dxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxh RCSB], [https://www.ebi.ac.uk/pdbsum/1dxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxh ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxh OCA], [http://www.ebi.ac.uk/pdbsum/1dxh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dxh RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/OTCC_PSEAE OTCC_PSEAE] Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.<ref>PMID:4962140</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dxh ConSurf].
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<div style="clear:both"></div>
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'''CATABOLIC ORNITHINE CARBAMOYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA'''
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==See Also==
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*[[Ornithine carbamoyltransferase 3D structures|Ornithine carbamoyltransferase 3D structures]]
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== References ==
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==Overview==
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<references/>
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The catabolic ornithine carbamoyltransferase (OTCase) from Pseudomonas aeruginosa exhibits allosteric behaviour, with two conformational states of the molecule: an active R form and an inactive T form. The enzyme is a dodecamer with a molecular mass of 455700 Da. Three crystal forms have been obtained. Crystals of allosteric state T are rhombohedral, belonging to the R3 space group, with hexagonal unit-cell parameters a = b = 180.6, c = 122.0 A. They diffract to a resolution of 4.5 A. Two crystal forms for allosteric state R have been obtained, with hexagonal and cubic symmetries. Hexagonal crystals, which diffract to a resolution of 3. 4 A, belong to the space group P6(3) with unit-cell parameters a = b = 140.8, c = 145.6 A. The cubic crystals belong to space group I23, with unit-cell parameter a = 134.32 A and diffract to a resolution better than 2.5 A. In all crystal forms, the dodecamer exhibits a 23 point-group symmetry.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1DXH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXH OCA].
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==Reference==
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Purification, crystallization and preliminary X-ray analysis of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa., Sainz G, Vicat J, Kahn R, Tricot C, Stalon V, Dideberg O, Acta Crystallogr D Biol Crystallogr. 1999 Sep;55(Pt 9):1591-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10489456 10489456]
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[[Category: Ornithine carbamoyltransferase]]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Dideberg O]]
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[[Category: Dideberg, O.]]
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[[Category: Duee E]]
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[[Category: Duee, E.]]
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[[Category: Kahn R]]
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[[Category: Kahn, R.]]
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[[Category: Sainz G]]
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[[Category: Sainz, G.]]
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[[Category: Stalon V]]
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[[Category: Stalon, V.]]
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[[Category: Tricot C]]
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[[Category: Tricot, C.]]
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[[Category: Vicat J]]
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[[Category: Vicat, J.]]
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[[Category: transcarbamylase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:50:43 2008''
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Current revision

Catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa

PDB ID 1dxh

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