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3hwj

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==Crystal structure of the second PHR domain of Mouse Myc-binding protein 2 (MYCBP-2)==
==Crystal structure of the second PHR domain of Mouse Myc-binding protein 2 (MYCBP-2)==
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<StructureSection load='3hwj' size='340' side='right' caption='[[3hwj]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='3hwj' size='340' side='right'caption='[[3hwj]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HWJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HWJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gbw|3gbw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hwj OCA], [https://pdbe.org/3hwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hwj RCSB], [https://www.ebi.ac.uk/pdbsum/3hwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hwj ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mycbp2, Pam, Phr1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hwj OCA], [http://pdbe.org/3hwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hwj RCSB], [http://www.ebi.ac.uk/pdbsum/3hwj PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYCB2_MOUSE MYCB2_MOUSE]] Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.<ref>PMID:14729956</ref>
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[https://www.uniprot.org/uniprot/MYCB2_MOUSE MYCB2_MOUSE] Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.<ref>PMID:14729956</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/3hwj_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/3hwj_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Atwell, S]]
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[[Category: Mus musculus]]
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[[Category: Bain, K T]]
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[[Category: Atwell S]]
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[[Category: Burley, S K]]
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[[Category: Bain KT]]
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[[Category: Gheyi, T]]
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[[Category: Burley SK]]
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[[Category: Klemke, R L]]
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[[Category: Gheyi T]]
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[[Category: Miller, S A]]
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[[Category: Klemke RL]]
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[[Category: Structural genomic]]
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[[Category: Miller SA]]
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[[Category: Ozyurt, S A]]
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[[Category: Ozyurt SA]]
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[[Category: Rutter, M E]]
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[[Category: Rutter ME]]
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[[Category: Sampathkumar, P]]
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[[Category: Sampathkumar P]]
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[[Category: Sauder, J M]]
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[[Category: Sauder JM]]
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[[Category: Wasserman, S R]]
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[[Category: Wasserman SR]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Myc-binding protein 2]]
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[[Category: Mycbp2]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Nucleus]]
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[[Category: Pam]]
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[[Category: Phosphoprotein]]
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[[Category: Phr domain]]
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[[Category: Phr protein]]
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[[Category: Phr1]]
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[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]
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[[Category: Protein associated with myc]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of the second PHR domain of Mouse Myc-binding protein 2 (MYCBP-2)

PDB ID 3hwj

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