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1wji
From Proteopedia
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==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3== | ==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3== | ||
| - | <StructureSection load='1wji' size='340' side='right' caption='[[1wji | + | <StructureSection load='1wji' size='340' side='right'caption='[[1wji]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJI FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wji OCA], [https://pdbe.org/1wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wji RCSB], [https://www.ebi.ac.uk/pdbsum/1wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wji ProSAT], [https://www.topsan.org/Proteins/RSGI/1wji TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wji_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wji_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Inoue | + | [[Category: Large Structures]] |
| - | [[Category: Kamatari | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kamatari YO]] |
| - | [[Category: Kobayashi | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Kobayashi N]] |
| - | [[Category: Li | + | [[Category: Koshiba S]] |
| - | [[Category: Miyamoto | + | [[Category: Li H]] |
| - | [[Category: Nakanishi | + | [[Category: Miyamoto K]] |
| - | + | [[Category: Nakanishi T]] | |
| - | [[Category: Tochio | + | [[Category: Tochio N]] |
| - | [[Category: Tomizawa | + | [[Category: Tomizawa T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3
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Categories: Homo sapiens | Large Structures | Inoue M | Kamatari YO | Kigawa T | Kobayashi N | Koshiba S | Li H | Miyamoto K | Nakanishi T | Tochio N | Tomizawa T | Yokoyama S
