2zz9

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==Structure of aquaporin-4 S180D mutant at 2.8 A resolution by electron crystallography==
==Structure of aquaporin-4 S180D mutant at 2.8 A resolution by electron crystallography==
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<StructureSection load='2zz9' size='340' side='right' caption='[[2zz9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='2zz9' size='340' side='right'caption='[[2zz9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zz9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZZ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d57|2d57]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aqp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zz9 OCA], [https://pdbe.org/2zz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2zz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zz9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zz9 OCA], [http://pdbe.org/2zz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zz9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AQP4_RAT AQP4_RAT]] Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space, as cerebrospinal fluid fills these structures it may facilitate water balance between brain parenchyma and the fluid compartment. In the plasma membranes of the neurons of the paraventricular and supraoptic nuclei, it may mediate rapid changes in cell volume in response to local shifts in extracellular osmolarity.
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[https://www.uniprot.org/uniprot/AQP4_RAT AQP4_RAT] Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space, as cerebrospinal fluid fills these structures it may facilitate water balance between brain parenchyma and the fluid compartment. In the plasma membranes of the neurons of the paraventricular and supraoptic nuclei, it may mediate rapid changes in cell volume in response to local shifts in extracellular osmolarity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zz9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zz9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Aquaporin|Aquaporin]]
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*[[Aquaporin 3D structures|Aquaporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Fujiyoshi, Y]]
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[[Category: Rattus norvegicus]]
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[[Category: Hiroaki, Y]]
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[[Category: Fujiyoshi Y]]
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[[Category: Kamegawa, A]]
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[[Category: Hiroaki Y]]
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[[Category: Mitsuma, T]]
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[[Category: Kamegawa A]]
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[[Category: Nishikawa, K]]
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[[Category: Mitsuma T]]
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[[Category: Tani, K]]
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[[Category: Nishikawa K]]
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[[Category: Tanimura, Y]]
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[[Category: Tani K]]
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[[Category: Aquaporin]]
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[[Category: Tanimura Y]]
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[[Category: Baculovirus expression system]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Phosphoprotein]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Two-dimensional crystal]]
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[[Category: Water channel]]
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[[Category: Water transport]]
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Current revision

Structure of aquaporin-4 S180D mutant at 2.8 A resolution by electron crystallography

PDB ID 2zz9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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