1nl1
From Proteopedia
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==BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION== | ==BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION== | ||
- | <StructureSection load='1nl1' size='340' side='right' caption='[[1nl1]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='1nl1' size='340' side='right'caption='[[1nl1]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1nl1]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1nl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NL1 FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nl1 OCA], [https://pdbe.org/1nl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nl1 ProSAT]</span></td></tr> | |
- | + | ||
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
- | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/1nl1_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/1nl1_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
- | *[[Thrombin|Thrombin]] | + | *[[Thrombin 3D Structures|Thrombin 3D Structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: Furie | + | [[Category: Furie B]] |
- | [[Category: Furie | + | [[Category: Furie BC]] |
- | [[Category: Huang | + | [[Category: Huang G]] |
- | [[Category: Huang | + | [[Category: Huang M]] |
- | [[Category: Seaton | + | [[Category: Seaton B]] |
- | + |
Current revision
BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION
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Categories: Bos taurus | Large Structures | Furie B | Furie BC | Huang G | Huang M | Seaton B