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2ch1
From Proteopedia
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==Structure of Anopheles gambiae 3-hydroxykynurenine transaminase== | ==Structure of Anopheles gambiae 3-hydroxykynurenine transaminase== | ||
| - | <StructureSection load='2ch1' size='340' side='right' caption='[[2ch1]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='2ch1' size='340' side='right'caption='[[2ch1]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ch1]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ch1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch1 OCA], [https://pdbe.org/2ch1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch1 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HKT_ANOGA HKT_ANOGA] Catalyzes the pyridoxal 5'-phosphate-dependent transamination of both 3-hydroxykynurenine and L-kynurenine to xanthurenic acid and kynurenic acid, respectively, preferentially using the alpha-ketoacid glyoxylate as the amino group acceptor (PubMed:16262702). Although glyoxylate is the preferred amino group acceptor, transamination of 3-hydroxykynurenine also works with pyruvate as the amino acceptor in vitro (PubMed:16262702). Involved in the detoxification of cytotoxic metabolite 3-hydroxykynurenine generated by the hydroxylation of L-kynurenine, an intermediate in the tryptophan catabolism pathway (PubMed:16262702). The Plasmodium parasite uses xanthurenic acid produced in the midgut to activate its gametocytes ingested during a blood meal (Probable). Also catalyzes, although with a lesser efficiency, the transamination of alanine with glyoxylate as an amino group acceptor (By similarity). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the diet (By similarity).[UniProtKB:Q0IG34]<ref>PMID:16262702</ref> <ref>PMID:16262702</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch1_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch1_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Anoga]] | ||
| - | [[Category: Arca, B]] | ||
| - | [[Category: Garavaglia, S]] | ||
| - | [[Category: Giovenzana, G B]] | ||
| - | [[Category: Li, J]] | ||
| - | [[Category: Rizzi, M]] | ||
| - | [[Category: Rossi, F]] | ||
| - | [[Category: 3-hydroxykynurenine transaminase]] | ||
[[Category: Anopheles gambiae]] | [[Category: Anopheles gambiae]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arca B]] |
| - | [[Category: | + | [[Category: Garavaglia S]] |
| + | [[Category: Giovenzana GB]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Rizzi M]] | ||
| + | [[Category: Rossi F]] | ||
Current revision
Structure of Anopheles gambiae 3-hydroxykynurenine transaminase
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Categories: Anopheles gambiae | Large Structures | Arca B | Garavaglia S | Giovenzana GB | Li J | Rizzi M | Rossi F
