1ows

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==Crystal structure of a C49 Phospholipase A2 from Indian cobra reveals carbohydrate binding in the hydrophobic channel==
==Crystal structure of a C49 Phospholipase A2 from Indian cobra reveals carbohydrate binding in the hydrophobic channel==
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<StructureSection load='1ows' size='340' side='right' caption='[[1ows]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='1ows' size='340' side='right'caption='[[1ows]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ows]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OWS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ows]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OWS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lfj|1lfj]], [[1lff|1lff]], [[1ln8|1ln8]], [[1mh2|1mh2]], [[1mh7|1mh7]], [[1mh8|1mh8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ows FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ows OCA], [https://pdbe.org/1ows PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ows RCSB], [https://www.ebi.ac.uk/pdbsum/1ows PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ows ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ows FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ows OCA], [http://pdbe.org/1ows PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ows RCSB], [http://www.ebi.ac.uk/pdbsum/1ows PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[https://www.uniprot.org/uniprot/PA2A2_NAJNA PA2A2_NAJNA] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/1ows_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/1ows_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Indian cobra]]
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[[Category: Large Structures]]
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[[Category: Jabeen, T]]
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[[Category: Naja naja]]
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[[Category: Jasti, J]]
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[[Category: Jabeen T]]
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[[Category: Kaur, P]]
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[[Category: Jasti J]]
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[[Category: Sharma, S]]
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[[Category: Kaur P]]
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[[Category: Singh, N]]
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[[Category: Sharma S]]
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[[Category: Singh, R K]]
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[[Category: Singh N]]
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[[Category: Singh, T P]]
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[[Category: Singh RK]]
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[[Category: Enzyme]]
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[[Category: Singh TP]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase]]
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[[Category: Phospholipid]]
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Current revision

Crystal structure of a C49 Phospholipase A2 from Indian cobra reveals carbohydrate binding in the hydrophobic channel

PDB ID 1ows

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