3l4c

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==Structural basis of membrane-targeting by Dock180==
==Structural basis of membrane-targeting by Dock180==
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<StructureSection load='3l4c' size='340' side='right' caption='[[3l4c]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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<StructureSection load='3l4c' size='340' side='right'caption='[[3l4c]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3l4c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L4C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3l4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L4C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOCK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4c OCA], [http://pdbe.org/3l4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l4c RCSB], [http://www.ebi.ac.uk/pdbsum/3l4c PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4c OCA], [https://pdbe.org/3l4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l4c RCSB], [https://www.ebi.ac.uk/pdbsum/3l4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l4c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DOCK1_HUMAN DOCK1_HUMAN]] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.<ref>PMID:8657152</ref>
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[https://www.uniprot.org/uniprot/DOCK1_HUMAN DOCK1_HUMAN] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.<ref>PMID:8657152</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/3l4c_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/3l4c_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3l4c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3l4c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bankston, L A]]
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[[Category: Large Structures]]
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[[Category: Bobkov, A A]]
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[[Category: Bankston LA]]
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[[Category: Cote, J-.F]]
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[[Category: Bobkov AA]]
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[[Category: Jaroszewski, L]]
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[[Category: Cote J-F]]
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[[Category: Liddington, R C]]
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[[Category: Jaroszewski L]]
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[[Category: Patel, M]]
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[[Category: Liddington RC]]
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[[Category: Premkumar, L]]
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[[Category: Patel M]]
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[[Category: Stec, B]]
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[[Category: Premkumar L]]
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[[Category: Vuori, K]]
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[[Category: Stec B]]
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[[Category: Apoptosis]]
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[[Category: Vuori K]]
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[[Category: Cell adhesion]]
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[[Category: Cell invasion]]
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[[Category: Cell migration]]
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[[Category: Cell polarity]]
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[[Category: Cytoskeleton]]
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[[Category: Dock1]]
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[[Category: Dock180]]
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[[Category: Guanine exchange factor]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Membrane]]
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[[Category: Phagocytosis]]
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[[Category: Phosphoinositide specificity]]
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[[Category: Phosphoprotein]]
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[[Category: Rho gtpase]]
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[[Category: Sh3 domain]]
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[[Category: Sh3-binding]]
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Current revision

Structural basis of membrane-targeting by Dock180

PDB ID 3l4c

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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