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3dry

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==X-ray crystal structure of human KCTD5 protein crystallized in low-salt buffer==
==X-ray crystal structure of human KCTD5 protein crystallized in low-salt buffer==
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<StructureSection load='3dry' size='340' side='right' caption='[[3dry]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='3dry' size='340' side='right'caption='[[3dry]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dry]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dry]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRY FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3drx|3drx]], [[3drz|3drz]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCTD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dry OCA], [https://pdbe.org/3dry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dry RCSB], [https://www.ebi.ac.uk/pdbsum/3dry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dry ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dry OCA], [http://pdbe.org/3dry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dry RCSB], [http://www.ebi.ac.uk/pdbsum/3dry PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCTD5_HUMAN KCTD5_HUMAN]] Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.<ref>PMID:18573101</ref>
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[https://www.uniprot.org/uniprot/KCTD5_HUMAN KCTD5_HUMAN] Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.<ref>PMID:18573101</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dry_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dry_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dementieva, I]]
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[[Category: Large Structures]]
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[[Category: Goldstein, S A.N]]
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[[Category: Dementieva I]]
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[[Category: Tereshko, V]]
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[[Category: Goldstein SAN]]
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[[Category: Btb/poz]]
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[[Category: Tereshko V]]
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[[Category: Golgi]]
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[[Category: Grasp55]]
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[[Category: Host-virus interaction]]
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[[Category: Kctd5]]
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[[Category: Nucleus]]
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[[Category: Pentameric assembly]]
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[[Category: Potassium channel domain t1]]
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[[Category: Unknown function]]
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Current revision

X-ray crystal structure of human KCTD5 protein crystallized in low-salt buffer

PDB ID 3dry

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