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1b8h

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==SLIDING CLAMP, DNA POLYMERASE==
==SLIDING CLAMP, DNA POLYMERASE==
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<StructureSection load='1b8h' size='340' side='right' caption='[[1b8h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1b8h' size='340' side='right'caption='[[1b8h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1b8h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpr69 Bpr69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1b8h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_RB69 Escherichia phage RB69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8H FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GENE 45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12353 BPR69])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8h OCA], [http://pdbe.org/1b8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b8h RCSB], [http://www.ebi.ac.uk/pdbsum/1b8h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8h OCA], [https://pdbe.org/1b8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8h RCSB], [https://www.ebi.ac.uk/pdbsum/1b8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPA5_BPR69 DPA5_BPR69]] Replisome sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. [[http://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69]] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
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[https://www.uniprot.org/uniprot/CLAMP_BPR69 CLAMP_BPR69] Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template. During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it.[HAMAP-Rule:MF_04161]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8h_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8h_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bpr69]]
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[[Category: Escherichia phage RB69]]
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[[Category: Shamoo, Y]]
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[[Category: Large Structures]]
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[[Category: Steitz, T A]]
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[[Category: Shamoo Y]]
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[[Category: Accessory protein]]
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[[Category: Steitz TA]]
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[[Category: Gp45]]
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[[Category: Replisome]]
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[[Category: Sliding clamp]]
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[[Category: Transferase]]
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Current revision

SLIDING CLAMP, DNA POLYMERASE

PDB ID 1b8h

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