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1ony
From Proteopedia
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==Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17== | ==Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17== | ||
| - | <StructureSection load='1ony' size='340' side='right' caption='[[1ony]], [[Resolution|resolution]] 2.15Å' scene=''> | + | <StructureSection load='1ony' size='340' side='right'caption='[[1ony]], [[Resolution|resolution]] 2.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ony]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1ony]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=588:2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC+ACID'>588</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ony FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ony OCA], [https://pdbe.org/1ony PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ony RCSB], [https://www.ebi.ac.uk/pdbsum/1ony PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ony ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1ony_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1ony_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Abad-Zapatero | + | [[Category: Abad-Zapatero C]] |
| - | [[Category: Ballaron | + | [[Category: Ballaron SJ]] |
| - | [[Category: Fesik | + | [[Category: Fesik SW]] |
| - | [[Category: Hadjuk | + | [[Category: Hadjuk PJ]] |
| - | [[Category: Hutchins | + | [[Category: Hutchins CW]] |
| - | [[Category: Janowich | + | [[Category: Janowich DA]] |
| - | [[Category: Jirousek | + | [[Category: Jirousek MR]] |
| - | [[Category: Liang | + | [[Category: Liang H]] |
| - | [[Category: Liu | + | [[Category: Liu G]] |
| - | [[Category: Lubben | + | [[Category: Lubben T]] |
| - | [[Category: Mika | + | [[Category: Mika AK]] |
| - | [[Category: Pei | + | [[Category: Pei Z]] |
| - | [[Category: Stashko | + | [[Category: Stashko MA]] |
| - | [[Category: Szczepankiewicz | + | [[Category: Szczepankiewicz BG]] |
| - | [[Category: Trevillyan | + | [[Category: Trevillyan JM]] |
| - | [[Category: Xin | + | [[Category: Xin Z]] |
| - | [[Category: Zinker | + | [[Category: Zinker BA]] |
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Current revision
Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17
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Categories: Homo sapiens | Large Structures | Abad-Zapatero C | Ballaron SJ | Fesik SW | Hadjuk PJ | Hutchins CW | Janowich DA | Jirousek MR | Liang H | Liu G | Lubben T | Mika AK | Pei Z | Stashko MA | Szczepankiewicz BG | Trevillyan JM | Xin Z | Zinker BA
