3ju4

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==Crystal Structure Analysis of EndosialidaseNF at 0.98 A Resolution==
==Crystal Structure Analysis of EndosialidaseNF at 0.98 A Resolution==
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<StructureSection load='3ju4' size='340' side='right' caption='[[3ju4]], [[Resolution|resolution]] 0.98&Aring;' scene=''>
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<StructureSection load='3ju4' size='340' side='right'caption='[[3ju4]], [[Resolution|resolution]] 0.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ju4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpk1f Bpk1f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JU4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ju4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_K1F Escherichia phage K1F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JU4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.98&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v0e|1v0e]], [[1v0f|1v0f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-alpha-sialidase Endo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.129 3.2.1.129] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ju4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ju4 OCA], [https://pdbe.org/3ju4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ju4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ju4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ju4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ju4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ju4 OCA], [http://pdbe.org/3ju4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ju4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ju4 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIBER_BPK1F FIBER_BPK1F] Responsible for initial absorption of the phage to the host bacterium. Degrades the alpha-2,8-linked polysialic acid K1 capsule by cleaving within the polymer chain of polysialic acid.<ref>PMID:20096705</ref> <ref>PMID:3546309</ref> The C-terminal chaperone protein mediates homotrimerization and proper folding of the catalytic endo-N trimer.<ref>PMID:12556457</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3ju4_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3ju4_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Neuraminidase|Neuraminidase]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bpk1f]]
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[[Category: Escherichia phage K1F]]
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[[Category: Endo-alpha-sialidase]]
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[[Category: Large Structures]]
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[[Category: Ficner, R]]
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[[Category: Ficner R]]
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[[Category: Gerardy-Schahn, R]]
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[[Category: Gerardy-Schahn R]]
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[[Category: Neuman, P]]
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[[Category: Neuman P]]
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[[Category: Schulz, E C]]
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[[Category: Schulz EC]]
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[[Category: Sheldrick, G M]]
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[[Category: Sheldrick GM]]
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[[Category: Endonf]]
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[[Category: Glycosidase]]
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[[Category: High-resolution]]
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[[Category: Hydrolase]]
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[[Category: Polysia]]
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Current revision

Crystal Structure Analysis of EndosialidaseNF at 0.98 A Resolution

PDB ID 3ju4

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