1ed3

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[[Image:1ed3.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.==
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|PDB= 1ed3 |SIZE=350|CAPTION= <scene name='initialview01'>1ed3</scene>, resolution 2.55&Aring;
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<StructureSection load='1ed3' size='340' side='right'caption='[[1ed3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ed3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ED3 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ed3 OCA], [https://pdbe.org/1ed3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ed3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ed3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ed3 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ed3 OCA], [http://www.ebi.ac.uk/pdbsum/1ed3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ed3 RCSB]</span>
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[https://www.uniprot.org/uniprot/HA12_RAT HA12_RAT] Involved in the presentation of foreign antigens to the immune system.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/1ed3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ed3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen. The antigenic structure of MTF-E was unpredictable due to its extraordinary length and two arginines that could serve as potential anchor residues. The crystal structure of RT1-Aa-MTF-E at 2.55 A shows that both peptide termini are anchored, as in other class I molecules, but the central residues in two independent pMHC complexes adopt completely different bulged conformations based on local environment. The MTF-E epitope is fully exposed within the putative T cell receptor (TCR) footprint. The flexibility demonstrated by the MTF-E structures illustrates how different TCRs may be raised against chemically identical, but structurally dissimilar, pMHC complexes.
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'''CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.'''
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Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa.,Speir JA, Stevens J, Joly E, Butcher GW, Wilson IA Immunity. 2001 Jan;14(1):81-92. PMID:11163232<ref>PMID:11163232</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ed3" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen. The antigenic structure of MTF-E was unpredictable due to its extraordinary length and two arginines that could serve as potential anchor residues. The crystal structure of RT1-Aa-MTF-E at 2.55 A shows that both peptide termini are anchored, as in other class I molecules, but the central residues in two independent pMHC complexes adopt completely different bulged conformations based on local environment. The MTF-E epitope is fully exposed within the putative T cell receptor (TCR) footprint. The flexibility demonstrated by the MTF-E structures illustrates how different TCRs may be raised against chemically identical, but structurally dissimilar, pMHC complexes.
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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==About this Structure==
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*[[MHC I 3D structures|MHC I 3D structures]]
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1ED3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED3 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa., Speir JA, Stevens J, Joly E, Butcher GW, Wilson IA, Immunity. 2001 Jan;14(1):81-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11163232 11163232]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Butcher, G W.]]
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[[Category: Butcher GW]]
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[[Category: Joly, E.]]
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[[Category: Joly E]]
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[[Category: Speir, J A.]]
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[[Category: Speir JA]]
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[[Category: Stevens, J.]]
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[[Category: Stevens J]]
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[[Category: Wilson, I A.]]
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[[Category: Wilson IA]]
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[[Category: cell surface receptor]]
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[[Category: cellular immunity]]
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[[Category: immunology]]
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[[Category: major histocompatibility complex]]
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[[Category: mhc]]
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[[Category: peptide antigen presentation]]
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[[Category: rat minor histocompatibility complex]]
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[[Category: t cell receptor ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:00:07 2008''
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Current revision

CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.

PDB ID 1ed3

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