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2wwe
From Proteopedia
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==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma== | ==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma== | ||
| - | <StructureSection load='2wwe' size='340' side='right' caption='[[2wwe]], [[Resolution|resolution]] 1.25Å' scene=''> | + | <StructureSection load='2wwe' size='340' side='right'caption='[[2wwe]], [[Resolution|resolution]] 1.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwe OCA], [https://pdbe.org/2wwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwe RCSB], [https://www.ebi.ac.uk/pdbsum/2wwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P3C2G_HUMAN P3C2G_HUMAN] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity).[UniProtKB:O70167][UniProtKB:O70173] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Phosphoinositide 3- | + | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Johansson | + | [[Category: Johansson A]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Kallas | + | [[Category: Kallas A]] |
| - | [[Category: Karlberg | + | [[Category: Karlberg T]] |
| - | [[Category: Kotyenova | + | [[Category: Kotyenova T]] |
| - | [[Category: Kotzch | + | [[Category: Kotzch A]] |
| - | [[Category: Kraulis | + | [[Category: Kraulis P]] |
| - | [[Category: Markova | + | [[Category: Markova N]] |
| - | [[Category: Moche | + | [[Category: Moche M]] |
| - | [[Category: Nielsen | + | [[Category: Nielsen TK]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Nyman | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | [[Category: Roos | + | [[Category: Roos AK]] |
| - | + | [[Category: Schuler H]] | |
| - | [[Category: Schuler | + | [[Category: Schutz P]] |
| - | [[Category: Schutz | + | [[Category: Siponen MI]] |
| - | [[Category: Siponen | + | [[Category: Svensson L]] |
| - | [[Category: Svensson | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Tresaugues L]] |
| - | [[Category: Tresaugues | + | [[Category: Van Der Berg S]] |
| - | [[Category: Wahlberg | + | [[Category: Wahlberg E]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Welin | + | [[Category: Welin M]] |
| - | [[Category: Wisniewska | + | [[Category: Wisniewska M]] |
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Current revision
Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Kallas A | Karlberg T | Kotyenova T | Kotzch A | Kraulis P | Markova N | Moche M | Nielsen TK | Nordlund P | Nyman T | Persson C | Roos AK | Schuler H | Schutz P | Siponen MI | Svensson L | Thorsell AG | Tresaugues L | Van Der Berg S | Wahlberg E | Weigelt J | Welin M | Wisniewska M
