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1ej6

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[[Image:1ej6.gif|left|200px]]
 
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{{Structure
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==Reovirus core==
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|PDB= 1ej6 |SIZE=350|CAPTION= <scene name='initialview01'>1ej6</scene>, resolution 3.6&Aring;
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<SX load='1ej6' size='340' side='right' viewer='molstar' caption='[[1ej6]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1ej6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJ6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ej6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ej6 OCA], [https://pdbe.org/1ej6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ej6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ej6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ej6 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ej6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ej6 OCA], [http://www.ebi.ac.uk/pdbsum/1ej6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ej6 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/LMBD2_REOVD LMBD2_REOVD] Outer capsid protein involved in mRNA capping. Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ej6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ej6 ConSurf].
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<div style="clear:both"></div>
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'''Reovirus core'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Overview==
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</SX>
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The reovirus core is an assembly with a relative molecular mass of 52 million that synthesizes, modifies and exports viral messenger RNA. Analysis of its structure by X-ray crystallography shows that there are alternative, specific and completely non-equivalent contacts made by several surfaces of two of its proteins; that the RNA capping and export apparatus is a hollow cylinder, which probably sequesters its substrate to ensure completion of the capping reactions; that the genomic double-stranded RNA is coiled into concentric layers within the particle; and that there is a protein shell that appears to be common to all groups of double-stranded RNA viruses.
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[[Category: Large Structures]]
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[[Category: Reovirus sp]]
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==About this Structure==
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[[Category: Harrison SC]]
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1EJ6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ6 OCA].
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[[Category: Nibert ML]]
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[[Category: Reinisch KM]]
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==Reference==
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Structure of the reovirus core at 3.6 A resolution., Reinisch KM, Nibert ML, Harrison SC, Nature. 2000 Apr 27;404(6781):960-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10801118 10801118]
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[[Category: Protein complex]]
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[[Category: Reovirus sp.]]
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[[Category: Harrison, S C.]]
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[[Category: Nibert, M L.]]
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[[Category: Reinisch, K M.]]
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[[Category: dsrna virus]]
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[[Category: guanylyltransferase]]
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[[Category: icosahedral]]
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[[Category: icosahedral virus]]
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[[Category: methylase]]
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[[Category: methyltransferase]]
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[[Category: non-equivalence]]
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[[Category: virus]]
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[[Category: zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:03:36 2008''
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Current revision

Reovirus core

1ej6, resolution 3.60Å

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OCA

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