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1xf1

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==Structure of C5a peptidase- a key virulence factor from Streptococcus==
==Structure of C5a peptidase- a key virulence factor from Streptococcus==
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<StructureSection load='1xf1' size='340' side='right' caption='[[1xf1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1xf1' size='340' side='right'caption='[[1xf1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xf1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XF1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xf1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XF1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">scpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xf1 OCA], [https://pdbe.org/1xf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xf1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xf1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xf1 OCA], [http://pdbe.org/1xf1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xf1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xf1 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C5AP_STRPY C5AP_STRPY] This virulence factor of S.pyogenes specifically cleaves the human serum chemotaxin C5a at '68-Lys-|-Asp-69' bond near its C-terminus, destroying its ability to serve as a chemoattractant.<ref>PMID:2406246</ref> <ref>PMID:3906656</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xf1_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xf1_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Micrococcus scarlatinae klein 1884]]
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[[Category: Large Structures]]
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[[Category: Brown, C K]]
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[[Category: Streptococcus pyogenes]]
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[[Category: Cleary, P P]]
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[[Category: Brown CK]]
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[[Category: Earhart, C A]]
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[[Category: Cleary PP]]
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[[Category: Gu, Z Y]]
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[[Category: Earhart CA]]
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[[Category: Matsuka, Y]]
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[[Category: Gu ZY]]
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[[Category: Ohlendorf, D H]]
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[[Category: Matsuka Y]]
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[[Category: Olmstead, S]]
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[[Category: Ohlendorf DH]]
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[[Category: C5a peptidase]]
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[[Category: Olmstead S]]
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[[Category: Hydrolase]]
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Current revision

Structure of C5a peptidase- a key virulence factor from Streptococcus

PDB ID 1xf1

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