2ahs
From Proteopedia
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==Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta== | ==Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta== | ||
| - | <StructureSection load='2ahs' size='340' side='right' caption='[[2ahs]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='2ahs' size='340' side='right'caption='[[2ahs]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ahs]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ahs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AHS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahs OCA], [https://pdbe.org/2ahs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahs RCSB], [https://www.ebi.ac.uk/pdbsum/2ahs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahs ProSAT]</span></td></tr> |
| - | < | + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PTPRB_HUMAN PTPRB_HUMAN] Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).<ref>PMID:19116766</ref> <ref>PMID:19136612</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/2ahs_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/2ahs_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Ball | + | [[Category: Ball L]] |
| - | [[Category: Barr | + | [[Category: Barr A]] |
| - | [[Category: Bray | + | [[Category: Bray J]] |
| - | [[Category: Bunkoczi | + | [[Category: Bunkoczi G]] |
| - | [[Category: Burgess | + | [[Category: Burgess N]] |
| - | [[Category: Das | + | [[Category: Das S]] |
| - | [[Category: Debreczeni | + | [[Category: Debreczeni J]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Eswaran J]] |
| - | [[Category: Eswaran | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Knapp S]] |
| - | [[Category: Knapp | + | [[Category: Sobott F]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sobott | + | [[Category: Turnbull A]] |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Ugochukwu | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Ball L | Barr A | Bray J | Bunkoczi G | Burgess N | Das S | Debreczeni J | Edwards A | Eswaran J | Gileadi O | Knapp S | Sobott F | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
