This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2w6b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:45, 13 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==CRYSTAL STRUCTURE OF THE TRIMERIC BETA-PIX COILED-COIL DOMAIN==
+
 
-
<StructureSection load='2w6b' size='340' side='right' caption='[[2w6b]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+
==Crystal Structure of the Trimeric beta-PIX Coiled-Coil Domain==
 +
<StructureSection load='2w6b' size='340' side='right'caption='[[2w6b]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2w6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W6B FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2w6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W6B FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ak5|2ak5]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w6b OCA], [http://pdbe.org/2w6b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w6b RCSB], [http://www.ebi.ac.uk/pdbsum/2w6b PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w6b OCA], [https://pdbe.org/2w6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w6b RCSB], [https://www.ebi.ac.uk/pdbsum/2w6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w6b ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ARHG7_RAT ARHG7_RAT] Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w6b_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w6b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 28: Line 31:
==See Also==
==See Also==
-
*[[Rho guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor]]
+
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
+
[[Category: Large Structures]]
-
[[Category: Rittinger, K]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Schlenker, O]]
+
[[Category: Rittinger K]]
-
[[Category: Arhgef7]]
+
[[Category: Schlenker O]]
-
[[Category: Beta-pix]]
+
-
[[Category: Cdc42]]
+
-
[[Category: Coiled-coil]]
+
-
[[Category: Cool]]
+
-
[[Category: Cool-1]]
+
-
[[Category: Git]]
+
-
[[Category: Git1]]
+
-
[[Category: Guanine-nucleotide releasing factor]]
+
-
[[Category: Pak]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Pix]]
+
-
[[Category: Rac1]]
+
-
[[Category: Sh3 domain]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal Structure of the Trimeric beta-PIX Coiled-Coil Domain

PDB ID 2w6b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w6b"
Personal tools