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2vda

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==SOLUTION STRUCTURE OF THE SECA-SIGNAL PEPTIDE COMPLEX==
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<StructureSection load='2vda' size='340' side='right' caption='[[2vda]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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==Solution structure of the SecA-signal peptide complex==
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<StructureSection load='2vda' size='340' side='right'caption='[[2vda]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDA FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tm6|1tm6]], [[1tf5|1tf5]], [[1m6n|1m6n]], [[2fsf|2fsf]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tm6|1tm6]], [[1tf5|1tf5]], [[1m6n|1m6n]], [[2fsf|2fsf]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [http://pdbe.org/2vda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [http://www.ebi.ac.uk/pdbsum/2vda PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vda OCA], [https://pdbe.org/2vda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vda RCSB], [https://www.ebi.ac.uk/pdbsum/2vda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vda ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).
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[[https://www.uniprot.org/uniprot/SECA_ECOLI SECA_ECOLI]] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.<ref>PMID:15140892</ref> [[https://www.uniprot.org/uniprot/LAMB_ECOL6 LAMB_ECOL6]] Involved in the transport of maltose and maltodextrins (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vda_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vda_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Bacillus coli migula 1895]]
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[[Category: Large Structures]]
[[Category: Bonvin, A M.J J]]
[[Category: Bonvin, A M.J J]]
[[Category: Economou, A]]
[[Category: Economou, A]]

Current revision

Solution structure of the SecA-signal peptide complex

PDB ID 2vda

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