2osa
From Proteopedia
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==The Rho-GAP domain of human N-chimaerin== | ==The Rho-GAP domain of human N-chimaerin== | ||
| - | <StructureSection load='2osa' size='340' side='right' caption='[[2osa]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='2osa' size='340' side='right'caption='[[2osa]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2osa]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2osa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osa OCA], [https://pdbe.org/2osa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osa RCSB], [https://www.ebi.ac.uk/pdbsum/2osa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osa ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN] Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:[https://omim.org/entry/604356 604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN] GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osa_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osa_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bochkarev A]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Hong BS]] |
| - | [[Category: | + | [[Category: Park HW]] |
| - | [[Category: Shen | + | [[Category: Shen L]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Walker | + | [[Category: Walker JR]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
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Current revision
The Rho-GAP domain of human N-chimaerin
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Edwards AM | Hong BS | Park HW | Shen L | Sundstrom M | Walker JR | Weigelt J
