3edt

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==Crystal structure of the mutated S328N hKLC2 TPR domain==
==Crystal structure of the mutated S328N hKLC2 TPR domain==
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<StructureSection load='3edt' size='340' side='right' caption='[[3edt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='3edt' size='340' side='right'caption='[[3edt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3edt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EDT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3edt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ceq|3ceq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edt OCA], [https://pdbe.org/3edt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edt RCSB], [https://www.ebi.ac.uk/pdbsum/3edt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3edt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edt OCA], [http://pdbe.org/3edt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3edt RCSB], [http://www.ebi.ac.uk/pdbsum/3edt PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLC2_HUMAN KLC2_HUMAN]] Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).
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[https://www.uniprot.org/uniprot/KLC2_HUMAN KLC2_HUMAN] Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3edt_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3edt_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Kinesin|Kinesin]]
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: MacKenzie, F]]
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[[Category: Edwards AM]]
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[[Category: Park, H]]
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[[Category: MacKenzie F]]
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[[Category: Structural genomic]]
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[[Category: Park H]]
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[[Category: Shen, Y]]
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[[Category: Shen Y]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Zhu, H]]
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[[Category: Zhu H]]
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[[Category: Microtubule]]
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[[Category: Motor protein]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Superhelical]]
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[[Category: Tpr repeat]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the mutated S328N hKLC2 TPR domain

PDB ID 3edt

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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