3iuy

<StructureSection load='3iuy' size='340' side='right' caption='[[3iuy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[3iuy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IUY FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDX53, CAGE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iuy OCA], [http://pdbe.org/3iuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iuy RCSB], [http://www.ebi.ac.uk/pdbsum/3iuy PDBsum]</span></td></tr>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/3iuy_consurf.spt"</scriptWhenChecked>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA remodeling is unknown. We present crystal structures of the isolated DEAD-domains of human DDX2A/eIF4A1, DDX2B/eIF4A2, DDX5, DDX10/DBP4, DDX18/myc-regulated DEAD-box protein, DDX20, DDX47, DDX52/ROK1, and DDX53/CAGE, and of the helicase domains of DDX25 and DDX41. Together with prior knowledge this enables a family-wide comparative structural analysis. We propose a general mechanism for opening of the RNA binding site. This analysis also provides insights into the diversity of DExD/H- proteins, with implications for understanding the functions of individual family members.

Comparative structural analysis of human DEAD-box RNA helicases.,Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H PLoS One. 2010 Sep 30;5(9). pii: e12791. PMID:20941364<ref>PMID:20941364</ref>

== References ==

[[Category: Human]]

[[Category: Arrowsmith, C H]]

[[Category: Berg, S Van Den]]

[[Category: Berglund, H]]

[[Category: Bountra, C]]

[[Category: Collins, R]]

[[Category: Edwards, A M]]

[[Category: Flodin, S]]

[[Category: Flores, A]]

[[Category: Graslund, S]]

[[Category: Hammarstrom, M]]

[[Category: Johansson, A]]

[[Category: Johansson, I]]

[[Category: Kallas, A]]

[[Category: Karlberg, T]]

[[Category: Kotenyova, T]]

[[Category: Kotzsch, A]]

[[Category: Kraulis, P]]

[[Category: Markova, N]]

[[Category: Moche, M]]

[[Category: Nielsen, T K]]

[[Category: Nordlund, P]]

[[Category: Nyman, T]]

[[Category: Persson, C]]

[[Category: Roos, A K]]

[[Category: Structural genomic]]

[[Category: Schuler, H M]]

[[Category: Schutz, P]]

[[Category: Siponen, M I]]

[[Category: Svensson, L]]

[[Category: Thorsell, A G]]

[[Category: Tresaugues, L]]

[[Category: Wahlberg, E]]

[[Category: Weigelt, J]]

[[Category: Welin, M]]

[[Category: Wisniewska, M]]

[[Category: Sgc]]