1lri

<StructureSection load='1lri' size='340' side='right' caption='[[1lri]], [[Resolution|resolution]] 1.45&Aring;' scene=''>

<table><tr><td colspan='2'>[[1lri]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LRI FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1beo|1beo]], [[1bxm|1bxm]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lri OCA], [http://pdbe.org/1lri PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lri RCSB], [http://www.ebi.ac.uk/pdbsum/1lri PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/ELIB_PHYCR ELIB_PHYCR]] Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane.

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lri_consurf.spt"</scriptWhenChecked>

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== Publication Abstract from PubMed ==

Cryptogein is a small 10 kDa elicitor produced by the phytoparasitic oomycete Phytophthora cryptogea. The protein also displays a sterol carrier activity. The native protein crystallizes in space group P4(1)22, with unit-cell parameters a = b = 46.51, c = 134.9 A (diffraction limit: 2.1 A). Its complex with cholesterol crystallizes in space group C222(1), with unit-cell parameters a = 30.96, b = 94.8, c = 65.3 A and a resolution enhanced to 1.45 A. The large inner non-specific hydrophobic cavity is able to accommodate a large variety of 3-beta-hydroxy sterols. Cryptogein probably acts as a sterol shuttle helping the pathogen to grow and complete its life cycle.

The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site.,Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1442-7. Epub 2002, Aug 23. PMID:12198300<ref>PMID:12198300</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Blein, J P]]

[[Category: Lascombe, M B]]

[[Category: Milat, M L]]

[[Category: Ponchet, M]]

[[Category: Prange, T]]

[[Category: Venard, P]]

[[Category: Toxin]]