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2fjn
From Proteopedia
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==The structure of phosphotyrosine phosphatase 1B in complex with compound 2== | ==The structure of phosphotyrosine phosphatase 1B in complex with compound 2== | ||
| - | <StructureSection load='2fjn' size='340' side='right' caption='[[2fjn]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='2fjn' size='340' side='right'caption='[[2fjn]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2fjn]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2fjn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJN FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=073:(4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC+ACID'>073</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=073:(4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC+ACID'>073</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fjn OCA], [https://pdbe.org/2fjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fjn RCSB], [https://www.ebi.ac.uk/pdbsum/2fjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fjn ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fjn_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fjn_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Asante-Appiah | + | [[Category: Asante-Appiah E]] |
| - | [[Category: Becker | + | [[Category: Becker JW]] |
| - | [[Category: Desponts | + | [[Category: Desponts C]] |
| - | [[Category: Dufresne | + | [[Category: Dufresne C]] |
| - | [[Category: Friesen | + | [[Category: Friesen R]] |
| - | [[Category: Kennedy | + | [[Category: Kennedy BP]] |
| - | [[Category: Lau | + | [[Category: Lau C]] |
| - | [[Category: Leblanc | + | [[Category: Leblanc Y]] |
| - | [[Category: Patel | + | [[Category: Patel S]] |
| - | [[Category: Scapin | + | [[Category: Scapin G]] |
| - | [[Category: Taylor | + | [[Category: Taylor JM]] |
| - | [[Category: Therien | + | [[Category: Therien M]] |
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Current revision
The structure of phosphotyrosine phosphatase 1B in complex with compound 2
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Categories: Homo sapiens | Large Structures | Asante-Appiah E | Becker JW | Desponts C | Dufresne C | Friesen R | Kennedy BP | Lau C | Leblanc Y | Patel S | Scapin G | Taylor JM | Therien M
